Schulz Lab

ALGOEPI 2022 - Computational Epigenomics

General info

• In-person lecture with exercises
• Lecture : Every Tuesday, time: 10:00 am, starting from the 26.4.2022 as in-person lecture. First lecture will be available as online video on the 12.4.2022.
• Exercise: Biweekly every Tuesday 4pm at room H IV (Bockenheim)
• You get 6 credit points
• Oral exams at the end of the semester, re-exams at the end of the break (exact dates tbd depending on the currect situation).
• Registration: Please register at the course mailing list if you are interested to join the course, additional information during the course will be announced over the list: register here
• Successful participation in excercises/assignments required to be eligible to take the exam

Course overview

Computational Epigenomics deals with the analysis of epigenomic modifications in the human genome. In multicellular organisms, such as we are, epigenetic modifications allow to change the access, storage and use of DNA in a cell-specific manner. These modifications change during development and disease and play thus important roles to understand genome regulation. In this course the foundations in epigenomics are explained. Foundations about Machine learning methods such as Hidden Markov Models and Sparse regression will be explained in context of modern algorithms and statistical approaches for the analysis of diverse expigenomics assays. The course is a mixture of theoretical knowledge concerning methods for the analysis of epigenomics data as well as hands-on experience for data analysis. In projects students will apply machine learning methods to human epigenomic data to learn about gene regulation.